產(chǎn)品介紹

 Huwentoxin-IV（虎紋捕鳥蛛神經(jīng)毒素-IV）  

TTX-S selective blocker(電壓門控鈉離子通道TTX-S選擇性阻斷劑)

Huwentoxin IV (HwTx-IV) is a neurotoxin that was originally isolated from Haplopelma schmidti (Chinese bird spider). This lethal neurotoxin acts selectively on tetrodotoxin-sensitive (TTX-S) voltage-gated sodium channels, with an IC₅₀ of 30 nM in rat DRG neurons. It preferentially inhibits neuronal voltage-gated sodium channel subtype hNa_v1.7 (SCN9A, IC₅₀ is 26 nM), rNa_v1.2 (SCN2A, IC₅₀ is 150 nM), and rNa_v1.3 (SCN3A, IC₅₀ is 338 nM), compared with muscle subtypes rNa_v1.4 (SCN4A) and hNa_v1.5 (SCN5A) (IC₅₀ is > 10 µM).Huwentoxin IV inhibits the activation of sodium channels by trapping the voltage sensor of domain II of the site 4 in the inward, closed configuration.

Huwentoxin-IV（虎紋捕鳥蛛神經(jīng)毒素-IV）技術(shù)資料

氨基酸序列：

Glu-Cys²-Leu-Glu-Ile-Phe-Lys-Ala-Cys⁹-Asn-Pro-Ser-Asn-Asp-Gln-Cys¹⁶-Cys¹⁷-Lys-Ser-Ser-Lys-Leu-Val-Cys²⁴-Ser-Arg-Lys-Thr-Arg-Trp-Cys³¹-Lys-Tyr-Gln-Ile-NH₂ 

二硫鍵：Cys²-Cys¹⁷, Cys⁹-Cys²⁴ and Cys¹⁶-Cys³¹ 

長度 (aa)：35 

分子式：C₁₇₄H₂₇₇N₅₁O₅₂S₆ 

分子量：4109.18 Da 

外觀：White lyophilized solid 

可溶性： water and saline buffer 

CAS 號：not available 

來源：Synthetic  

純度：> 97 %

產(chǎn)品信息